A role for multiple chimeric antigen receptor-expressing leukocytes in antigen-specific responses to cancer
Carmen SM Yong, Liza B John, Christel Devaud, Miles H Prince, Ricky W Johnstone, Joseph A Trapani, Phillip K Darcy, Michael H Kershaw
ONCOTARGET | IMPACT JOURNALS LLC | Published : 2016
While adoptive immunotherapy using chimeric antigen receptor (CAR)-modified T cells can induce remission of some tumors, the role of other CAR-modified leukocytes is not well characterized. In this study, we characterize the function of leukocytes including natural killer (NK) cells, macrophages and CAR T cells from transgenic mice expressing a CAR under the control of the pan-hematopoietic promoter, vav, and determine the ability of these mice to respond to ERB expressing tumors. We demonstrate the anti-tumor functions of leukocytes, including antigen specific cytotoxicity and cytokine secretion. The adoptive transfer of CAR T cells provided a greater survival advantage in the E0771ERB tumo..View full abstract
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Awarded by Cancer Council of Victoria, Australia
Awarded by National Health and Medical Research Council (NHMRC) of Australia
This work was supported by grants from the Cancer Council of Victoria, Australia (1066554), The Peter MacCallum Cancer Centre Foundation, and the National Health and Medical Research Council (NHMRC) of Australia (1103352). CSMY was supported by an Australian Postgraduate Award and Cancer Therapeutics Australia Scholarship. RWJ was supported by Senior Principal Research Fellowship from the NHMRC. MHK and PKD were supported by Senior Research Fellowships from the NHMRC.