N-acetylcysteine in depressive symptoms and functionality: A systematic review and meta-analysis

Abstract

Objective: To assess the utility of N-acetylcysteine administration for depressive symptoms in subjects with psychiatric conditions using a systematic review and meta-analysis. Data Sources: A computerized literature search was conducted in MEDLINE, Embase, the Cochrane Library, SciELO, PsycINFO, Scopus, and Web of Knowledge. No year or country restrictions were used. The Boolean terms used for the electronic database search were (NAC OR N-acetylcysteine OR acetylcysteine) AND (depression OR depressive OR depressed) AND (trial). The last search was performed in November 2014. Study Selection: The literature was searched for double-blind, randomized, placebocontrolled trials using N-acetylcys..