Journal article

Tumor-Suppressor Functions of the TP53 Pathway

Brandon J Aubrey, Andreas Strasser, Gemma L Kelly

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT | Published : 2016

Abstract

The fundamental biological importance of the Tp53 gene family is highlighted by its evolutionary conservation for more than one billion years dating back to the earliest multicellular organisms. The TP53 protein provides essential functions in the cellular response to diverse stresses and safeguards maintenance of genomic integrity, and this is manifest in its critical role in tumor suppression. The importance of Tp53 in tumor prevention is exemplified in human cancer where it is the most frequently detected genetic alteration. This is confirmed in animal models, in which a defective Tp53 gene leads inexorably to cancer development, whereas reinstatement of TP53 function results in regressio..

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Grants

Awarded by Kay Kendall Leukaemia Fund Intermediate Fellowship


Awarded by National Health and Medical Research Council, Australia


Awarded by Cancer Council Victoria


Awarded by Leukemia and Lymphoma Society SCOR Grant


Funding Acknowledgements

The authors thank Drs. Marco J. Herold, Daniel H.D. Gray, Jerry M. Adams, Suzanne Cory, and Ana Janic for insightful discussions and advice, and Cameron Wells and Rachel Bucknall for assistance with graphic design. This work is supported by a Leukaemia Foundation National Research Program Clinical PhD Scholarship (B.J.A.), a Kay Kendall Leukaemia Fund Intermediate Fellowship (KKL331 to G.L.K.), a National Health and Medical Research Council, Australia, Program Grant 1016701 (A.S.) and Fellowship 1020363 (A.S.), Project Grant 1086291 from the National Health and Medical Research Council, Australia (G.L.K.), a Cancer Council Victoria Grant-in-Aid 1086157 (G.L.K), and a Leukemia and Lymphoma Society SCOR Grant 7001-13 (A.S.). This work is made possible through Victorian State Government Operational Infrastructure Support and Australian Government National Health and Medical Research Council Independent Research Institutes Infrastructure Support Scheme.