Journal article

Neuronal activity-dependent regulation of retinal blood flow

Jonathan E Noonan, Ecosse L Lamoureux, Marc Sarossy



Blood flow in the retina is intrinsically regulated to meet the metabolic demands of its constituent cells. Flickering light or stationary contrast reversals induce an increase in blood flow within seconds of the stimulus onset. This phenomenon is thought to compensate for an increase in ganglion cell activity and energy consumption. Ganglion cell activity is in turn dependent on signals from photoreceptors, bipolar cells, horizontal cells and amacrine cells. The physiological properties of these neurons determine how each type is affected by a particular light characteristic. Neuronal activity then triggers the release of signalling molecules that dilate local blood vessels and increase blo..

View full abstract


Awarded by Australian NHMRC Postgraduate Medical Scholarship

Awarded by Australian NHMRC Research Fellowship

Funding Acknowledgements

The Centre for Eye Research Australia receives Operational Infrastructure Support from the Victorian Government. JN was supported by the Australian NHMRC Postgraduate Medical Scholarship (ID1038701). EL was supported by the Australian NHMRC Research Fellowship (ID1045280).