Persistence of glaucoma therapy and visual field progression

Abstract

Purpose: To determine the association of visual field (VF) progression with medication persistence in a cohort on glaucoma therapy. Patients and Methods: Pharmacy records were examined over 3 years for patients started on glaucoma monotherapy. A patient was persistent if a prescription was refilled for the same medication 5 reliable VFs within 1-year pretherapy and 6-year posttherapy were included. Progression was analyzed with pointwise linear regression and defined using 2 criteria: (A) Z2 adjacent progressing points (slope P<0.01) in 1 hemifield; and (B) Z3 progressing points (slope P<0.01). The mean number and mean slope of progressing points and the mean global slopes were determined. R..