Journal article
Transforming growth factor-β and Notch ligands act as opposing environmental cues in regulating the plasticity of type 3 innate lymphoid cells
C Viant, LC Rankin, MJH Girard-Madoux, C Seillet, W Shi, MJ Smyth, L Bartholin, T Walzer, ND Huntington, E Vivier, GT Belz
Science Signaling | AMER ASSOC ADVANCEMENT SCIENCE | Published : 2016
Abstract
Group 3 innate lymphoid cells (ILC3s) are composed of subsets that are either positive or negative for the natural cytotoxicity receptor (NCR) NKp46 (encoded by Ncr1). ILC3s are located at mucosal sites, such as in the intestine and lung, where they are exposed to billions of commensal microbes and potentially harmful pathogens. Together with T cells, the various ILC3 subsets maintain the balance between homeostasis and immune activation. Through genetic mapping, we identified a previously uncharacterized subset of NCR- ILC3s in mice that transiently express Ncr1, demonstrating previously undescribed heterogeneity within the ILC3 population. In addition, we showed that sustained Notch signal..
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Awarded by Australian Research Council
Funding Acknowledgements
The laboratory of E.V. is supported by the European Research Council (THINK Advanced Grant), the Ligue Nationale contre le Cancer (Equipe Labellisee), and institutional grants from INSERM, CNRS, and Aix-Marseille University to CIML. E.V. is a scholar of the Institut Universitaire de France. This work was supported by grants and fellowships from the NHMRC of Australia (GNT 1027472, 1054925, 1049407, and 1078671 to G.T.B., C.S., N.D.H., and M.J.S.), an NHMRC Dora Lush Postgraduate Research Scholarship (to L.C.R.), and an Australian Research Council Future Fellowship (to G.T.B.). This work was made possible through Victorian State Government Operational Infrastructure Support and Australian Government NHMRC IRIIS.