Insulin pump basal adjustment for exercise in type 1 diabetes: a randomised crossover study

SA McAuley; JC Horsburgh; GM Ward; A La Gerche; JL Gooley; AJ Jenkins; RJ MacIsaac; DN O’Neal

Journal article

Insulin pump basal adjustment for exercise in type 1 diabetes: a randomised crossover study

SA McAuley, JC Horsburgh, GM Ward, A La Gerche, JL Gooley, AJ Jenkins, RJ MacIsaac, DN O’Neal

Diabetologia | SPRINGER | Published : 2016

DOI: 10.1007/s00125-016-3981-9

Abstract

Aims/hypothesis: The aim of this study was to investigate the effects of exercise, vs rest, on circulating insulin and glucose, following pre-exercise insulin pump basal rate reduction. Methods: This was an open-label, two-stage randomised crossover study of 14 adults (seven women, seven men) with type 1 diabetes established on insulin pump therapy. In each stage, participants fasted and insulin delivery was halved following a single insulin basal rate overnight. Exercise (30 min moderate-intensity stationary bicycle exercise, starting 60 min post-basal reduction) and rest stages were undertaken in random order at a university hospital. Randomisation was computer-generated, and allocation co..

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University of Melbourne Researchers

Sybil McAuley Author

Glenn Ward Author

Andre La Gerche Author

Judith Gooley Author

Grants

Funding Acknowledgements

This project was funded by grants from the Australian Diabetes Society ADS-Sanofi Diabetes Research Grant programme, the Medical Research & Technology in Victoria programme supported by The Hugh DT Williamson Foundation, and the Lynne Quayle Charitable Trust Fund managed by Equity Trustees. SAM is supported by a University of Melbourne postgraduate scholarship. ALG is supported by a Career Development Scholarship from the National Health and Medical Research Council and a Future Leaders Fellowship from the National Heart Foundation of Australia. AJJ is supported by a Sydney Medical School Fellowship from the University of Sydney.