Insulin pump basal adjustment for exercise in type 1 diabetes: a randomised crossover study
Sybil A McAuley, Jodie C Horsburgh, Glenn M Ward, Andre La Gerche, Judith L Gooley, Alicia J Jenkins, Richard J MacIsaac, David N O'Neal
DIABETOLOGIA | SPRINGER | Published : 2016
AIMS/HYPOTHESIS: The aim of this study was to investigate the effects of exercise, vs rest, on circulating insulin and glucose, following pre-exercise insulin pump basal rate reduction. METHODS: This was an open-label, two-stage randomised crossover study of 14 adults (seven women, seven men) with type 1 diabetes established on insulin pump therapy. In each stage, participants fasted and insulin delivery was halved following a single insulin basal rate overnight. Exercise (30 min moderate-intensity stationary bicycle exercise, starting 60 min post-basal reduction) and rest stages were undertaken in random order at a university hospital. Randomisation was computer-generated, and allocation co..View full abstract
This project was funded by grants from the Australian Diabetes Society ADS-Sanofi Diabetes Research Grant programme, the Medical Research & Technology in Victoria programme supported by The Hugh DT Williamson Foundation, and the Lynne Quayle Charitable Trust Fund managed by Equity Trustees. SAM is supported by a University of Melbourne postgraduate scholarship. ALG is supported by a Career Development Scholarship from the National Health and Medical Research Council and a Future Leaders Fellowship from the National Heart Foundation of Australia. AJJ is supported by a Sydney Medical School Fellowship from the University of Sydney.