Journal article
DNA Repair Genes: Alternative Transcription and Gene Expression at the Exon Level in Response to the DNA Damaging Agent, Ionizing Radiation
HB Forrester, J Li, D Hovan, AN Ivashkevich, CN Sprung
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2012
Abstract
DNA repair is an essential cellular process required to maintain genomic stability. Every cell is subjected to thousands of DNA lesions daily under normal physiological conditions. Ionizing radiation (IR) is a major DNA damaging agent that can be produced by both natural and man-made sources. A common source of radiation exposure is through its use in medical diagnostics or treatments such as for cancer radiotherapy where relatively high doses are received by patients. To understand the detailed DNA repair gene transcription response to high dose IR, gene expression exon array studies have been performed and the response to radiation in two divergent cell types, lymphoblastoid cell lines and..
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Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
This project was supported through the 2010 round of the priority-driven Collaborative Cancer Research Scheme (grant 1002743) and funded by the Australian Government Department of Health and Ageing with the assistance of Cancer Australia. Also, this work was supported by the Australian National Health and Medical Research Council (grant numbers 145780, 288713; http://www.nhmrc.gov.au/); the Australian National Breast Cancer Foundation (grant PG-08-06; http://www.nbcf.org.au/); and the National Institutes of Health (grant 5U19AI067773-07). Support was also provided by the Victorian Government's Operational Infrastructure Support Program. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.