Journal article
Opposite associations between alanine aminotransferase and γ-glutamyl transferase levels and all-cause mortality in type 2 diabetes: Analysis of the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study
KH Williams, DR Sullivan, GC Nicholson, J George, AJ Jenkins, AS Januszewski, VJ Gebski, P Manning, YM Tan, MW Donoghoe, C Ehnholm, S Young, R O'Brien, L Buizen, SM Twigg, AC Keech
Metabolism Clinical and Experimental | W B SAUNDERS CO-ELSEVIER INC | Published : 2016
Abstract
Aims Reported associations between liver enzymes and mortality may not hold true in type 2 diabetes, owing to a high prevalence of non-alcoholic fatty liver disease, which has been linked to cardiovascular disease and mortality in its own right. Our study aimed to determine whether alanine aminotransferase (ALT) or γ-glutamyl transferase (GGT) levels predict mortality in type 2 diabetes, and to examine possible mechanisms. Methods Data from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study were analyzed to examine the relationship between liver enzymes and all-cause and cause-specific mortality over 5 years. Results Over 5 years, 679 (6.9%) individuals died. After adj..
View full abstractGrants
Awarded by Abbott Fund
Funding Acknowledgements
KHW was the recipient of a National Health and Medical Research Council (NHMRC) Medical and Dental Research Scholarship. Work conducted by KHW has also been supported by the Australian branch of the Thessalian Society and the Diabetes Research Foundation, University of Sydney. The study was partly supported by funding from the NHMRC to the NHMRC Clinical Trials Centre (Program Grant 1037786). The FIELD study was funded by Fournier Laboratories (now Abbott).