Further examination of the reducing transition rate in ultra high risk for psychosis samples: The possible role of earlier intervention

B Nelson; HP Yuen; A Lin; SJ Wood; PD McGorry; JA Hartmann; AR Yung

Journal article

Further examination of the reducing transition rate in ultra high risk for psychosis samples: The possible role of earlier intervention

B Nelson, HP Yuen, A Lin, SJ Wood, PD McGorry, JA Hartmann, AR Yung

SCHIZOPHRENIA RESEARCH | ELSEVIER SCIENCE BV | Published : 2016

DOI: 10.1016/j.schres.2016.04.040

Abstract

BACKGROUND: The rate of transition to psychotic disorder in ultra high risk (UHR) patients has declined in recent cohorts. The reasons for this are unclear, but may include a lead-time bias, earlier intervention, a change in clinical characteristics of cohorts, and treatment changes. AIMS: In this paper we examined the two possibilities related to reduction in duration of symptoms prior to clinic entry, i.e., lead-time bias and earlier intervention. METHOD: The sample consisted of all UHR research participants seen at the PACE clinic, Melbourne between 1993 and 2006 (N=416), followed for a mean of 7.5years (the 'PACE 400' cohort). Duration of symptoms was analysed by four baseline year time ..

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University of Melbourne Researchers

Hok Yuen Author Centre for Youth Mental Health

Stephen Wood Author Centre for Youth Mental Health

Patrick McGorry Author Centre for Youth Mental Health

Barnaby Nelson Author Centre for Youth Mental Health

Alison Yung Author Centre for Youth Mental Health

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Grants

Awarded by National Health and Medical Research Council (NHMRC) Program

Awarded by Netherlands Organisation for Scientific Research

Awarded by NHMRC Career Development Fellowship

Awarded by NHMRC Clinical Career Developmental Award

Awarded by NHMRC Senior Research Fellowship

Awarded by NHMRC Early Career Fellowship

Funding Acknowledgements

We acknowledge the funding support of the National Health and Medical Research Council (NHMRC) Program grants 350241 and 566529 (awarded to PM, ARY and SJW) and the Colonial Foundation. JAH was supported by a Rubicon Fellowship from the Netherlands Organisation for Scientific Research (NWO 825.15.015), BN was supported by an NHMRC Career Development Fellowship (1027532), SJW was supported by an NHMRC Clinical Career Developmental Award (359223), and ARY was supported by an NHMRC Senior Research Fellowship (566593). AL was supported by a NHMRC Early Career Fellowship (1072593).