Environmental enrichment imparts disease-modifying and transgenerational effects on genetically-determined epilepsy and anxiety
Gabi Dersi, Ezgi Ozturk, Michael R Salzberg, Margaret Morris, Terence J O'Brien, Nigel C Jones
NEUROBIOLOGY OF DISEASE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2016
INTRODUCTION: The absence epilepsies are presumed to be caused by genetic factors, but the influence of environmental exposures on epilepsy development and severity, and whether this influence is transmitted to subsequent generations, is not well known. We assessed the effects of environmental enrichment on epilepsy and anxiety outcomes in multiple generations of GAERS - a genetic rat model of absence epilepsy that manifests comorbid elevated anxiety-like behaviour. METHODS: GAERS were exposed to environmental enrichment or standard housing beginning either prior to, or after epilepsy onset, and underwent EEG recordings and anxiety testing. Then, we exposed male GAERS to early enrichment or ..View full abstract
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Awarded by ARC
TO, MS, MM, NJ received funding from the NHMRC project grant scheme for this work (#566843 and #1059860). NJ received funding from the NHMRC Career Development Award scheme (#628466) and from the ARC Future Fellowship scheme (#13100100). The remaining authors report no conflicts of interest associated with this work.