Journal article

Uterine morphology during diapause and early pregnancy in the tammar wallaby (Macropus eugenii)

Melanie K Laird, Cyrma M Hearn, Geoff Shaw, Marilyn B Renfree

Journal of Anatomy | WILEY-BLACKWELL | Published : 2016


In mammals, embryonic diapause, or suspension of embryonic development, occurs when embryos at the blastocyst stage are arrested in growth and metabolism. In the tammar wallaby (Macropus eugenii), there are two separate uteri, only one of which becomes gravid with the single conceptus at a post-partum oestrus, so changes during pregnancy can be compared between the gravid and non-gravid uterus within the same individual. Maintenance of the viable blastocyst and inhibition of further conceptus growth during diapause in the tammar is completely dependent on the uterine environment. Although the specific endocrine and seasonal signals are well established, much less is known about the cellular ..

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Funding Acknowledgements

GS, MBR and CMH collected the tissue used in this study. CMH undertook all technical work including tissue preparation and microscopy, prepared figures and interpreted the results. GS assisted with the figures. MKL prepared the manuscript. MBR and GS advised with experimental design and all authors assisted in manuscript preparation. This work was supported by grants from the Australian Research Council to MBR, GS and Dr Richard Behringer (MD Anderson Cancer Center, University of Texas, Houston).