Journal article

Childhood gene-environment interactions and age-dependent effects of genetic variants associated with refractive error and myopia: The CREAM Consortium

Qiao Fan, Xiaobo Guo, J Willem L Tideman, Katie M Williams, Seyhan Yazar, S Mohsen Hosseini, Laura D Howe, Beate St Pourcain, David M Evans, Nicholas J Timpson, George McMahon, Pirro G Hysi, Eva Krapohl, Ya Xing Wang, Jost B Jonas, Paul Nigel Baird, Jie Jin Wang, Ching-Yu Cheng, Yik-Ying Teo, Tien-Yin Wong Show all

Scientific Reports | NATURE PUBLISHING GROUP | Published : 2016

Grants

Awarded by Wellcome Trust


Awarded by UK Medical Research Council


Awarded by Hong Kong Polytechnic University


Awarded by National Institutes of Health (NIH)/National Eye Institute (NEI)


Awarded by NHMRC


Awarded by National Science Foundation


Awarded by Fundamental Research Funds for the State Key Laboratory, NSFC


Awarded by Fundamental Research Funds for the Central Universities


Awarded by Australian National Health and Medical Research Council (NHMRC)


Awarded by NMRC


Awarded by US National Institutes of Health


Awarded by Medical Research Council Research Professorship award


Awarded by European Research Council Advanced Investigator award


Awarded by National Eye Institute, National Institutes of Health


Awarded by NIH


Awarded by Medical Research Council


Awarded by National Institute for Health Research


Funding Acknowledgements

ALSPAC. We are extremely grateful to all the families who took part in this study, the midwives for their help in recruiting them, and the whole ALSPAC team, which includes interviewers, computer and laboratory technicians, clerical workers, research scientists, volunteers, managers, receptionists and nurses. The UK Medical Research Council and the Wellcome Trust (Grant ref: 102215/2/13/2) and the University of Bristol provide core support for ALSPAC. This publication is the work of the authors and JAG and CW will serve as guarantors for the contents of this paper. This research was specifically funded by grant MC_UU_12013/3&4 from the UK Medical Research Council and grant Z0GM from the Hong Kong Polytechnic University. GWAS data were generated by Sample Logistics and Genotyping Facilities at the Wellcome Trust Sanger Institute and LabCorp (Laboratory Corportation of America) using support from 23andMe.BATS and TEST. The Australian Twin Registry is supported by an Australian National Health and Medical Research Council (NHMRC) Enabling Grant (2004-2009). Part of the genotyping was funded by an NHMRC Medical Genomics Grant. Genotyping for the remainder was performed by the National Institutes of Health (NIH)/National Eye Institute (NEI) grant RO1EY018246 and a Center for Inherited Diseases Research (CIDR) genotyping project grant both awarded to Terri L. Young (PI), and we are grateful to Dr Camilla Day and staff. Ophthalmic examination of the Twin cohorts was funded by the Clifford Craig Medical Research Trust, Ophthalmic Research Institute of Australia (ORIA), American Health Assistance Foundation (AHAF), Peggy and Leslie Cranbourne Foundation, Foundation for Children, NHMRC Project Grant 350415 (2005-2007), Jack Brockhoff Foundation and the Pfizer Australia Senior Research Fellowship (DAM). We also would like to acknowledge that CERA receives Operational Infrastructure Support from the Victorian Government. The Berghofer QIMR authors thank the twins eye study investigators; Nicholas G Martin, Scott D. Gordon, Anjali K. Henders, Sarah E. Medland, Brian McEvoy, Dale R. Nyholt, Margaret J. Wright, Megan J. Campbell, and Anthony Caracella for their assistance in processing the Australian genotyping data. We are also grateful for Jane MacKinnon, Shayne Brown, Sandra Staffieri, Olivia Bigault, Colleen Wilkinson, Julie Barbour, Byoung Sung Chu, Jonathan Ruddle Paul Sanfilippo, Cong Sun, Justin Sherwin, Robert Macmillan, Rachael Adams, Robyn Troutbeck, Ya Ling Ma, Christine Chen and Amy Cohn In addition, we appreciate the assistance in recruiting twins from Thanuja Gunasekera, Allison McKenzie, Anne-Louise Ponsonby, Terry Dwyer, James Dilger, Palma Ragno, Jenny Boadle, Kim Dorrell, Shyamali Dharmage, John HopperGZT. We are extremely grateful to all the twins and their parents, and the whole Guangzhou Twins team which includes research scientists, interviewers, statistician, laboratory technicians, clerical workers, volunteers, managers, receptionists, nurses and graduate students. The Guangzhou Twin Eye study is supported by National Science Foundation for Distinguished Young Scholars (81125007), Fundamental Research Funds for the Central Universities, Fundamental Research Funds for the State Key Laboratory, NSFC(11401600), the Fundamental Research Funds for the Central Universities (15lgpy07) and the free application projects from the SYSU-CMU Shunde International Joint Research Institute.RAINE. We are grateful to all the study participants. We also thank the Raine Study and Lions Eye Institute (LEI) research staff for cohort coordination and data collection. The core management of the Raine Study is funded by The University of Western Australia (UWA), The Telethon Institute for Child Health Research, Raine Medical Research Foundation, UWA Faculty of Medicine, Dentistry and Health Sciences, Women's and Infant's Research Foundation and Curtin University. Genotyping was funded by Australian National Health and Medical Research Council (NHMRC) project grant 1021105. Support for the REHS was provided by LEI, the Australian Foundation for the Prevention of Blindness and Ophthalmic Research Institute of Australia (ORIA).SCORM: We wish to express our gratitude to all the participants and patients who volunteered to take part in this study. The SCORM GWAS study was supported by the Singapore BioMedical Research Council (BMRC). Additional support was provided by the Singapore Tissue Network. We acknowledge the Genome Institute of Singapore for genotyping all the samples collected from SCORM.STARS: The Strabismus, Amblyopia, and Refractive Error Study of Preschool Children (STARS) was supported by a NMRC grant (1176/2008). We acknowledge the Genome Institute of Singapore for genotyping all the samples collected from STARS.TEDS. We gratefully acknowledge the ongoing contribution of the participants in the Twins Early Development Study (TEDS) and their families. TEDS is supported by a program grant to Robert Plomin from the UK Medical Research Council [G0901245; previously G0500079], with additional support from the US National Institutes of Health [HD044454 and HD059215]. RP is supported by a Medical Research Council Research Professorship award [G19/2] and a European Research Council Advanced Investigator award [295366]. KMW is supported by a Medical Research Council Clinical Research Training Fellowship. EK is supported by an Institute of Psychiatry, Psychology and Neuroscience Excellence Studentship.WESDR. The WESDR was supported by grant R01-EY016379 from the National Eye Institute, National Institutes of Health and an unrestricted grant from Research to Prevent Blindness, New York, NY.JEBW is supported by the Intramural Research Program of the National Human Genome Research Institute, NIH. TLY is supported by Research to Prevent Blindness, Inc., and NIH NEI R01EY014685.