Journal article
The caspase-8 inhibitor emricasan combines with the SMAC mimetic birinapant to induce necroptosis and treat acute myeloid leukemia
Gabriela Brumatti, Chunyan Ma, Najoua Lalaoui, Nhu-Y Nguyen, Mario Navarro, Maria C Tanzer, Jennifer Richmond, Margherita Ghisi, Jessica M Salmon, Natasha Silke, Giovanna Pomilio, Stefan P Glaser, Elisha de Valle, Raffi Gugasyan, Mark A Gurthridge, Stephen M Condon, Ricky W Johnstone, Richard Lock, Guy Salvesen, Andrew Wei Show all
Science Translational Medicine | AMER ASSOC ADVANCEMENT SCIENCE | Published : 2016
Grants
Awarded by Leukemia & Lymphoma Society [SCOR (Specialized Center of Research)]
Awarded by National Health and Medical Research Council (NHMRC)
Awarded by NHMRC
Awarded by NHMRC Independent Research Institutes Infrastructure Support Scheme
Awarded by NIH
Funding Acknowledgements
This work was supported by a grant from the Leukemia & Lymphoma Society [SCOR (Specialized Center of Research) grant 7001-06 to D.L.V.], the National Health and Medical Research Council (NHMRC; grants 461221, 1025594, 1046010, and 1081376), NHMRC fellowships (grants 541901 and 1058190 to J.S.), and an Association pour le Recherche contre le Cancer (ARC) fellowship to N.L. with additional support from the Australian Cancer Research Foundation, the Victorian State Government Operational Infrastructure Support, and the NHMRC Independent Research Institutes Infrastructure Support Scheme (grant 361646). G.S. and M.N. are supported by NIH (grants RO1GM099040 and 5 R01CA163743). R.L. is supported by an NHMRC fellowship (1059804).