Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem-like Cells

Julie Giraud; Laura M Failla; Jean-Marc Pascussi; Ebba L Lagerqvist; Jeremy Ollier; Pascal Finetti; Francois Bertucci; Chu Ya; Imene Gasmi; Jean-Francois Bourgaux; Michel Prudhomme; Thibault Mazard; Imade Ait-Arsa; Leila Houhou; Daniel Birnbaum; Andre Pelegrin; Charles Vincent; James G Ryall; Dominique Joubert; Julie Pannequin; Frederic Hollande

Journal article

Autocrine Secretion of Progastrin Promotes the Survival and Self-Renewal of Colon Cancer Stem-like Cells

Julie Giraud, Laura M Failla, Jean-Marc Pascussi, Ebba L Lagerqvist, Jeremy Ollier, Pascal Finetti, Francois Bertucci, Chu Ya, Imene Gasmi, Jean-Francois Bourgaux, Michel Prudhomme, Thibault Mazard, Imade Ait-Arsa, Leila Houhou, Daniel Birnbaum, Andre Pelegrin, Charles Vincent, James G Ryall, Dominique Joubert, Julie Pannequin Show all

CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2016

DOI: 10.1158/0008-5472.CAN-15-1497

Abstract

Subpopulations of cancer stem-like cells (CSC) are thought to drive tumor progression and posttreatment recurrence in multiple solid tumors. However, the mechanisms that maintain stable proportions of self-renewing CSC within heterogeneous tumors under homeostatic conditions remain poorly understood. Progastrin is a secreted peptide that exhibits tumor-forming potential in colorectal cancer, where it regulates pathways known to modulate colon CSC behaviors. In this study, we investigated the role of progastrin in regulating CSC phenotype in advanced colorectal cancer. Progastrin expression and secretion were highly enriched in colon CSC isolated from human colorectal cancer cell lines and co..

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University of Melbourne Researchers

Frederic Hollande Author Clinical Pathology

James Ryall Author Anatomy and Physiology

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Grants

Awarded by National Health and Medical Research Council (NH&MRC) of Australia

Funding Acknowledgements

This work was supported by the French National Research Agency (ANR, PACCT grant), the Association pour la Recherche contre le Cancer (ARC), and by the Department of Pathology, University of Melbourne. J. Giraud was supported by scholarships from the MRT and from FRM. F. Hollande is supported by the National Health and Medical Research Council (NH&MRC) of Australia (#1049561).