Journal article
miRNA-362-3p is associated with recurrence of colorectal cancer and targets E2F1, USF2 and PTPN1
Heidi Tobiasen, Lise Lotte Christensen, Anja Holm, Troels Schepeler, Kasper Thorsen, Mads H Rasmussen, Karin Birkenkamp-Demtroeder, Oliver M Sieber, Peter Gibbs, Philippe Lamy, Soren Laurberg, Bodil Oster, Kristian Q Hansen, Rikke Hagemann-Madsen, Kristina Byskov, Torben F Orntoft, Claus L Andersen
CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2012
Abstract
Abstract Colorectal cancer (CRC) is one of the leading causes of cancer death in Western countries. A significant number of CRC patients undergoing curative-intented surgery subsequently develop recurrence and die from the disease. MicroRNAs (miRNAs) are aberrantly expressed in cancers and appear to have both diagnostic and prognostic significance. In this study we identified novel miRNAs associated with recurrence of CRC. TaqMan® Human MicroRNA Array Set v2.0 was used to profile the expression of 667 miRNAs in 14 normal colon mucosas and 46 microsatellite stable CRC tumors. Four miRNAs (miR-362-3p, miR-570, miR-148a* and miR-944) were expressed at a lower level in the tumors ..
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