Australian contemporary management of synchronous metastatic colorectal cancer

Abstract

Introduction: This article outlines the current Australian multidisciplinary treatment of synchronous metastatic colorectal adenocarcinoma and assesses the factors that influence patient outcome. Methods: This is a retrospective analysis of the prospective ‘Treatment of Recurrent and Advanced Colorectal Cancer’ registry, describing the patient treatment pathway and documenting the extent of disease, resection of the colorectal primary and metastases, chemotherapy and biological therapy use. Cox regression models for progression-free and overall survival were constructed with a comprehensive set of clinical variables. Analysis was intentionn-ton-treat, quantifying the effect of treatment inte..