Relationship between circulating sex steroid hormone concentrations and incidence of total knee and hip arthroplasty due to osteoarthritis in men

SM Hussain; Flavia M Cicuttini; GG Giles; SE Graves; Y Wang

Journal article

Relationship between circulating sex steroid hormone concentrations and incidence of total knee and hip arthroplasty due to osteoarthritis in men

SM Hussain, Flavia M Cicuttini, GG Giles, SE Graves, Y Wang

OSTEOARTHRITIS AND CARTILAGE | ELSEVIER SCI LTD | Published : 2016

DOI: 10.1016/j.joca.2016.04.008

Abstract

OBJECTIVE: Few studies have examined the association between circulating sex steroid concentrations and risk of osteoarthritis (OA) in men with inconsistent results. Our aim was to examine whether concentrations of circulating sex steroid hormones were associated with the incidence of primary knee and hip arthroplasty for OA in a prospective cohort study. DESIGN: Two thousand four hundred and ninety four men from the Melbourne Collaborative Cohort Study (MCCS) had circulating sex steroid concentrations measured in blood samples drawn at recruitment (1990-1994) and stored in liquid nitrogen. The plasma concentrations of sex hormones, including dehydroepiandrosterone sulphate, androstenedione,..

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University of Melbourne Researchers

Graham Giles Author Melbourne School of Population and Global Health

Monira Hussain Author Medical Education

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Grants

Awarded by National Health and Medical Research Council (NHMRC)

Awarded by NHMRC Career Development Fellowship

Funding Acknowledgements

The recruitment of the Melbourne Collaborative Cohort Study was funded by Vic Health and Cancer Council Victoria. This study was funded by a program grant from the National Health and Medical Research Council (NHMRC; 209057), capacity building grant (251533), and enabling grant (396414), and was further supported by infrastructure provided by Cancer Council Victoria. SMH is the recipient of AFA-ARA Heald fellowship funded by Australian Rheumatology Association. YW is the recipient of an NHMRC Career Development Fellowship (Clinical level 1, #1065464).