Journal article

Understanding the pathophysiology of schizophrenia: Contributions from the Melbourne Psychiatric Brain Bank

Brian Dean, David Copolov, Elizabeth Scarr



The Melbourne Psychiatric Brain Bank came into existence 25years ago. This review focusses on lines of research that have used tissue from the Brain Bank over periods of time. Hence there is a discussion on the significance of changes in levels of serotonin 2A receptors in the cortex of patients with schizophrenia and the relevance of such changes with regards to the pathophysiology of the disorder. The extensive contribution made by studies using tissue from the Melbourne Psychiatric Brain Bank to understanding the role of muscarinic receptors in the pathophysiology and treatment of schizophrenia is summarised. Finally, findings using brain bank tissue and "omics" technologies are reviewed...

View full abstract


Awarded by National Health and Medical Research Council

Awarded by Australian Research Council

Awarded by National Institute of Mental Health

Awarded by NHMRC Project Grant

Awarded by NHMRC Fellowship

Funding Acknowledgements

The authors would like to thank all those who have contributed to the creation and maintenance of the Melbourne Psychiatric Brain Bank that now forms part of the Victorian Brain Bank Network. The Victorian Brain Bank Network is supported by the Florey Institute for Neuroscience and Mental Health, the Alfred Hospital, the Victorian Forensic Institute of Medicine, the University of Melbourne and funded by Australia's National Health & Medical Research Council, Helen Macpherson Smith Trust, Parkinson's Victoria and Perpetual Philanthropic Services. The research described in this review, that was completed by the authors, was possible because of sustained funding from the National Health and Medical Research Council in the form of Research Fellowships (BD: APP1002240, 400016), Enabling Grant Funding (282933), Program Grants (923301) and funding from Project Grants (APP1048544, APP1045619, APP1066144, 566967, 509333, 350344, 209046, 193299, 114253). Additional funding was from the Australian Research Council (ES: Future Fellowship FT100100689), the National Institute of Mental Health (MH069691-01A1), Australian Rotary (ES: the Royce Abbey Post-doctoral Fellowship), the CRC for Mental Health, the Rebecca Cooper Medical Research Foundation, NHMRC Project Grant APP1045619 and the Victorian Government's Operational Infrastructure Support. BD is the recipient of an NHMRC Fellowship (APP1002240). ES was supported by the Australian Research Council (Future Fellowship FT100100689).