Nanoengineered Templated Polymer Particles: Navigating the Biological Realm
Jiwei Cui, Joseph J Richardson, Mattias Bjornmalm, Matthew Faria, Frank Caruso
ACCOUNTS OF CHEMICAL RESEARCH | AMER CHEMICAL SOC | Published : 2016
Nanoengineered materials offer tremendous promise for developing the next generation of therapeutics. We are transitioning from simple research questions, such as "can this particle eradicate cancer cells?" to more sophisticated ones like "can we design a particle to preferentially deliver cargo to a specific cancer cell type?" These developments are poised to usher in a new era of nanoengineered drug delivery systems. We primarily work with templating methods for engineering polymer particles and investigate their biological interactions. Templates are scaffolds that facilitate the formation of particles with well-controlled size, shape, structure, stiffness, stability, and surface chemistr..View full abstract
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Awarded by ARC under the Australian Laureate Fellowship
Awarded by ARC Centre of Excellence in Convergent Bio-Nano Science and Technology
This work was supported by the ARC under the Australian Laureate Fellowship (Grant FL120100030, F.C.) and through the ARC Centre of Excellence in Convergent Bio-Nano Science and Technology (Project Number CE140100036). J.J.R acknowledges the OCE Scheme.