Journal article

Nanoengineered Templated Polymer Particles: Navigating the Biological Realm

Jiwei Cui, Joseph J Richardson, Mattias Bjornmalm, Matthew Faria, Frank Caruso

ACCOUNTS OF CHEMICAL RESEARCH | AMER CHEMICAL SOC | Published : 2016

Abstract

Nanoengineered materials offer tremendous promise for developing the next generation of therapeutics. We are transitioning from simple research questions, such as "can this particle eradicate cancer cells?" to more sophisticated ones like "can we design a particle to preferentially deliver cargo to a specific cancer cell type?" These developments are poised to usher in a new era of nanoengineered drug delivery systems. We primarily work with templating methods for engineering polymer particles and investigate their biological interactions. Templates are scaffolds that facilitate the formation of particles with well-controlled size, shape, structure, stiffness, stability, and surface chemistr..

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