Breast Cancer Risk From Modifiable and Nonmodifiable Risk Factors Among White Women in the United States

P Maas; M Barrdahl; AD Joshi; PL Auer; MM Gaudet; RL Milne; FR Schumacher; WF Anderson; D Check; S Chattopadhyay; L Baglietto; CD Berg; SJ Chanock; DG Cox; JD Figueroa; MH Gail; BI Graubard; CA Haiman; SE Hankinson; RN Hoover; C Isaacs; LN Kolonel; L Le Marchand; IM Lee; S Lindström; K Overvad; I Romieu; MJ Sanchez; MC Southey; DO Stram; R Tumino; TJ VanderWeele; WC Willett; S Zhang; JE Buring; F Canzian; SM Gapstur; BE Henderson; DJ Hunter; GG Giles; RL Prentice; RG Ziegler; P Kraft; M Garcia-Closas; N Chatterjee

Journal article

Breast Cancer Risk From Modifiable and Nonmodifiable Risk Factors Among White Women in the United States

P Maas, M Barrdahl, AD Joshi, PL Auer, MM Gaudet, RL Milne, FR Schumacher, WF Anderson, D Check, S Chattopadhyay, L Baglietto, CD Berg, SJ Chanock, DG Cox, JD Figueroa, MH Gail, BI Graubard, CA Haiman, SE Hankinson, RN Hoover Show all

JAMA Oncology | AMER MEDICAL ASSOC | Published : 2016

DOI: 10.1001/jamaoncol.2016.1025

Abstract

Importance: An improved model for risk stratification can be useful for guiding public health strategies of breast cancer prevention.Objective: To evaluate combined risk stratification utility of common low penetrant single nucleotide polymorphisms (SNPs) and epidemiologic risk factors.Design, Setting, and Participants: Using a total of 17 171 cases and 19 862 controls sampled from the Breast and Prostate Cancer Cohort Consortium (BPC3) and 5879 women participating in the 2010 National Health Interview Survey, a model for predicting absolute risk of breast cancer was developed combining information on individual level data on epidemiologic risk factors and 24 genotyped SNPs from prospective ..

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University of Melbourne Researchers

Roger Milne Author

Melissa Southey Author

Graham Giles Author

Grants

Awarded by National Cancer Institute

Funding Acknowledgements

Design and conduct of the study; collection, management, analysis and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication was supported by US National Institutes of Health, National Cancer Institute (cooperative agreements U01-CA98233-07 to Dr Hunter, U01-CA98710-06 to M.J.T., U01-CA98216-06 to E.R. and R.K., and U01-CA98758-07 to Dr Henderson) and Intramural Research Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services. The WHI program is funded by the National Heart, Lung, and Blood Institute, National Institutes of Health, US Department of Health and Human Services through contracts HHSN268201100046C, HHSN268201100001C, HHSN268201100002C, HHSN268201100003C, HHSN268201100004C, and HHSN271201100004C. EPIC Greece is funded by the Hellenic Health Association and the Stavros Niarchos Foundation.