Journal article
Diversification of TOLLIP isoforms in mouse and man
YLS Lo, AG Beckhouse, SL Boulus, CA Wells
Mammalian Genome | SPRINGER | Published : 2009
Abstract
The Toll-interacting protein TOLLIP is an ubiquitin-binding protein that interacts with several components of the Toll-like receptor signaling cascade. The canonical protein consists of three annotated domains: an N-terminal TBD-loop-coil domain that mediates protein-protein interactions, a C2 domain that targets TOLLIP to the endosome, and a CUE domain at the C-terminus that binds monoubiquitin. TOLLIP has been described primarily in trafficking of the interleukin-1 receptor (IL1R) and turnover of the interleukin-1 receptor-associated kinase (IRAK), so it is an essential regulator of inflammatory signaling. Here we describe the expression of numerous alternate transcripts from mouse and hum..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The authors thank Mr. Andrew Pritchard for technical laboratory assistance, and Simone Chmielewski and Ms. Jo McLintock for their invaluable assistance managing the mouse colonies. This work was supported by the Australian Research Council ( grant DP0665078), which also provided YSL with a Ph. D. scholarship. AGB was funded through Australian federal government support of the National Centre for Adult Stem Cell Research. CAW was supported by the National Health and Medical Research Council Career Development Award CDA_481945.