Journal article
Nrf2 activation restores disease related metabolic deficiencies in olfactory neurosphere-derived cells from patients with sporadic parkinson's disease
AL Cook, AM Vitale, S Ravishankar, N Matigian, GT Sutherland, J Shan, R Sutharsan, C Perry, PA Silburn, GD Mellick, ML Whitelaw, CA Wells, A Mackay-Sim, SA Wood
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2011
Abstract
Background: Without appropriate cellular models the etiology of idiopathic Parkinson's disease remains unknown. We recently reported a novel patient-derived cellular model generated from biopsies of the olfactory mucosa (termed olfactory neurosphere-derived (hONS) cells) which express functional and genetic differences in a disease-specific manner. Transcriptomic analysis of Patient and Control hONS cells identified the NRF2 transcription factor signalling pathway as the most differentially expressed in Parkinson's disease. Results: We tested the robustness of our initial findings by including additional cell lines and confirmed that hONS cells from Patients had 20% reductions in reduced glu..
View full abstractGrants
Funding Acknowledgements
This work was supported by an Australian Department of Health and Ageing grant to AM-S. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.