Journal article
IL-12 and related cytokines: Function and regulatory implications in Candida albicans infection
RB Ashman, D Vijayan, CA Wells
Clinical and Developmental Immunology | HINDAWI LTD | Published : 2011
DOI: 10.1155/2011/686597
Open access
Abstract
IL-12 is a cytokine with links to both innate and adaptive immunity systems. In mice, its deletion leads to acute susceptibility to oral infection with the yeast Candida albicans, whereas such mice are resistant to systemic disease. However, it is an essential component of the adaptive response that leads to the generation of Th1-type cytokine responses and protection against disseminated disease. This paper presents an overview of the role of IL-12 in models of systemic and mucosal infection and the possible relationships between them. Copyright © 2011 Robert B. Ashman et al.
Grants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
C. A. Wells is recipient of a Research Career Development Award from the National Health and Medical Council of Australia (CDA481945). The authors thank the NHMRC and the Australian Dental Research Foundation, for research support.