Complex Loci in human and mouse genomes.

PG Engström; H Suzuki; N Ninomiya; A Akalin; L Sessa; G Lavorgna; A Brozzi; L Luzi; SL Tan; L Yang; G Kunarso; ELC Ng; S Batalov; C Wahlestedt; C Kai; J Kawai; P Carninci; Y Hayashizaki; C Wells; VB Bajic; V Orlando; JF Reid; B Lenhard; L Lipovich

Journal article

Complex Loci in human and mouse genomes.

PG Engström, H Suzuki, N Ninomiya, A Akalin, L Sessa, G Lavorgna, A Brozzi, L Luzi, SL Tan, L Yang, G Kunarso, ELC Ng, S Batalov, C Wahlestedt, C Kai, J Kawai, P Carninci, Y Hayashizaki, C Wells, VB Bajic Show all

PLoS genetics | PUBLIC LIBRARY SCIENCE | Published : 2006

DOI: 10.1371/journal.pgen.0020047

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Abstract

Mammalian genomes harbor a larger than expected number of complex loci, in which multiple genes are coupled by shared transcribed regions in antisense orientation and/or by bidirectional core promoters. To determine the incidence, functional significance, and evolutionary context of mammalian complex loci, we identified and characterized 5,248 cis-antisense pairs, 1,638 bidirectional promoters, and 1,153 chains of multiple cis-antisense and/or bidirectionally promoted pairs from 36,606 mouse transcriptional units (TUs), along with 6,141 cis-antisense pairs, 2,113 bidirectional promoters, and 1,480 chains from 42,887 human TUs. In both human and mouse, 25% of TUs resided in cis-antisense pair..

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