Journal article

Epigenetic modifications: mechanisms of disease and biomarkers of food allergy

David J Martino, Richard Saffery, Katrina J Allen, Susan L Prescott

CURRENT OPINION IN IMMUNOLOGY | CURRENT BIOLOGY LTD | Published : 2016

Abstract

The rise in IgE-mediated food allergy in recent times is the likely result of gene-environment interactions mediated via epigenetic pathways. As epigenetic modifications, including DNA methylation, are at the interface between the environment and the genome, they may be ideal biomarkers of modifiable disease pathways. High-throughput methylation profiling of immune cell subtypes or whole blood from patients allows the identification of disease specific epigenetic variants. If faithfully tracking with disease parameters, these 'signatures' may have clinical applications as biomarkers of disease or therapeutic response. Development of such tools will depend on a number of factors, including de..

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