Of sex and determination: marking 25 years of Randy, the sex-reversed mouse
Peter Koopman, Andrew Sinclair, Robin Lovell-Badge
DEVELOPMENT | COMPANY OF BIOLOGISTS LTD | Published : 2016
On Thursday 9 May 1991, the world awoke to front-page news of a breakthrough in biological research. From Washington to Wollongong, newspapers, radio and TV were abuzz with the story of a transgenic mouse in London called Randy. Why was this mouse so special? The mouse in question was a chromosomal female (XX) made male by the presence of a transgene containing the Y chromosome gene Sry This sex-reversal provided clear experimental proof that Sry was the elusive mammalian sex-determining gene. Twenty-five years on, we reflect on what this discovery meant for our understanding of how males and females arise and what remains to be understood.
Awarded by Medical Research Council
Awarded by The Francis Crick Institute
Awarded by Worldwide Cancer Research
Awarded by MRC