Journal article
The Burden of Cryptosporidium Diarrheal Disease among Children < 24 Months of Age in Moderate/High Mortality Regions of Sub-Saharan Africa and South Asia, Utilizing Data from the Global Enteric Multicenter Study (GEMS)
SO Sow, K Muhsen, D Nasrin, WC Blackwelder, Y Wu, TH Farag, S Panchalingam, D Sur, AKM Zaidi, ASG Faruque, D Saha, R Adegbola, PL Alonso, RF Breiman, Q Bassat, B Tamboura, D Sanogo, U Onwuchekwa, B Manna, T Ramamurthy Show all
Plos Neglected Tropical Diseases | PUBLIC LIBRARY SCIENCE | Published : 2016
Abstract
Background: The importance of Cryptosporidium as a pediatric enteropathogen in developing countries is recognized. Methods: Data from the Global Enteric Multicenter Study (GEMS), a 3-year, 7-site, case-control study of moderate-to-severe diarrhea (MSD) and GEMS-1A (1-year study of MSD and less-severe diarrhea [LSD]) were analyzed. Stools from 12,110 MSD and 3,174 LSD cases among children aged <60 months and from 21,527 randomly-selected controls matched by age, sex and community were immunoassay-tested for Cryptosporidium. Species of a subset of Cryptosporidium-positive specimens were identified by PCR; GP60 sequencing identified anthroponotic C. parvum. Combined annual Cryptosporidium-attri..
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Awarded by Medical Research Council
Funding Acknowledgements
This work was supported by grants 38774 and OPP1033572 from the Bill & Melinda Gates Foundation to MML, URL of the funder's website: http://www.gatesfoundation.org/. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.