Journal article

Frizzled7: A Promising Achilles' Heel for Targeting the Wnt Receptor Complex to Treat Cancer

Toby Phesse, Dustin Flanagan, Elizabeth Vincan

CANCERS | MDPI | Published : 2016

Abstract

Frizzled7 is arguably the most studied member of the Frizzled family, which are the cognate Wnt receptors. Frizzled7 is highly conserved through evolution, from Hydra through to humans, and is expressed in diverse organisms, tissues and human disease contexts. Frizzled receptors can homo- or hetero-polymerise and associate with several co-receptors to transmit Wnt signalling. Notably, Frizzled7 can transmit signalling via multiple Wnt transduction pathways and bind to several different Wnt ligands, Frizzled receptors and co-receptors. These promiscuous binding and functional properties are thought to underlie the pivotal role Frizzled7 plays in embryonic developmental and stem cell function...

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Grants

Awarded by National Health and Medical Research Council of Australia (NHMRC)


Awarded by Melbourne Health


Awarded by Cancer Council of Victoria (CCV)


Funding Acknowledgements

The authors wish to thank Gavan Mitchell for helping generate the figure in this manuscript. Funding from National Health and Medical Research Council of Australia (NHMRC, 566679 and APP1099302), Melbourne Health (605030 and PG-002) and the Cancer Council of Victoria (CCV, APP1020716) project grants awarded to Elizabeth Vincan / Toby Phesse; and a CCV postgraduate scholarship awarded to Dustin Flanagan are gratefully acknowledged.