A Role of Influenza Virus Exposure History in Determining Pandemic Susceptibility and CD8( ) T Cell Responses

Sergio M Quinones-Parra; E Bridie Clemens; Zhongfang Wang; Hayley A Croom; Lukasz Kedzierski; Jodie McVernon; Dhanasekaran Vijaykrishna; Katherine Kedzierska

Journal article

A Role of Influenza Virus Exposure History in Determining Pandemic Susceptibility and CD8( ) T Cell Responses

Sergio M Quinones-Parra, E Bridie Clemens, Zhongfang Wang, Hayley A Croom, Lukasz Kedzierski, Jodie McVernon, Dhanasekaran Vijaykrishna, Katherine Kedzierska

JOURNAL OF VIROLOGY | AMER SOC MICROBIOLOGY | Published : 2016

DOI: 10.1128/JVI.00349-16

Abstract

UNLABELLED: Novel influenza viruses often cause differential infection patterns across different age groups, an effect that is defined as heterogeneous demographic susceptibility. This occurred during the A/H2N2 pandemic, when children experienced higher influenza attack rates than adults. Since the recognition of conserved epitopes across influenza subtypes by CD8(+) cytotoxic T lymphocytes (CTLs) limit influenza disease, we hypothesized that conservation of CTL antigenic peptides (Ag-p) in viruses circulating before the pH2N2-1957 may have resulted in differential CTL immunity. We compared viruses isolated in the years preceding the pandemic (1941 to 1957) to which children and adults were..

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University of Melbourne Researchers

Zhongfang Wang Author Microbiology and Immunology

Lukasz Kedzierski Author Veterinary and Agricultural Sciences

Bridie Clemens Author Microbiology and Immunology

Katherine Kedzierska Author Microbiology and Immunology

Jodie McVernon Author Infectious Diseases

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Grants

Awarded by Australian National Health and Medical Research Council (NHMRC)

Awarded by National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, USA

Funding Acknowledgements

This work was supported by Australian National Health and Medical Research Council (NHMRC) project grant GNT1008854 and program grant GNT1071916 to Katherine Kedzierska. Sergio M. Quinones-Parra was supported by a University of Melbourne International Research Scholarship and was a CONACyT scholar. Dhanasekaran Vijaykrishna is supported by the Duke-NUS Signature Research Program funded by the Agency of Science, Technology and Research, Singapore, and the Ministry of Health, Singapore, and by contract HHSN272201400006C from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, USA.