Journal article

Assessment of polygenic effects links primary open-angle glaucoma and age-related macular degeneration

Gabriel Cuellar-Partida, Jamie E Craig, Kathryn P Burdon, Jie Jin Wang, Brendan J Vote, Emmanuelle Souzeau, Ian L McAllister, Timothy Isaacs, Stewart Lake, David A Mackey, Ian J Constable, Paul Mitchell, Alex W Hewitt, Stuart MacGregor

Scientific Reports | NATURE PUBLISHING GROUP | Published : 2016


Awarded by Center for Inherited Diseases Research

Awarded by NIH/NEI

Awarded by National Health and Medical Research Council (NHMRC) of Australia

Awarded by National Health and Medical Research Council ( NHMRC), Australia


Funding Acknowledgements

We thank the International AMD Genomics Consortium for carrying out the genotyping of the participants in this study. Genotyping for International AMD Genomics Consortium was funded through The Center for Inherited Diseases Research (HHSN268201200008I), as well as NIH/NEI grants 1X01HG006934-01 (to Goncalo R. Abecasis) and EY022310 (to Jonathan L. Haines). GCP thanks the University of Queensland and QIMR Berghofer Medical Research Institute for scholarship support. SM is supported by an Australian Research Council Future Fellowship. The UWA, LEI & Flinders group acknowledges financial support for participant recruitment and sample processing provided by the National Health and Medical Research Council (NHMRC) of Australia (#1023911), the Ophthalmic Research Institute of Australia, the BrightFocus Foundation and a Ramaciotti Establishment Grant. KPB, JEC and AWH are supported by NHMRC Fellowships. The authors acknowledge the support of B. Usher-Ridge, L. Palmer, L. Ma and DL Lim in patient recruitment and data collection. The Westmead/Sydney samples were collected in three studies that were supported by the National Health and Medical Research Council ( NHMRC), Australia: Grant IDs 974159, 211069, 457349 and 512423 supported the Blue Mountains Eye Study that provided population-based controls; Grant ID 302010 supported the Cataract Surgery and Risk of Age-related Macular Degeneration study that provided clinic-based early and late AMD cases and controls; and Grant ID 571013 supported the Genes and environment in late AMD study that provided clinic-based late AMD cases. The NHMRC had no role in the design or conduct of these studies.