No difference between aspirin and warfarin after extracardiac Fontan in a propensity score analysis of 475 patients

AJ Iyengar; D S.Winlaw; JC Galati; GR Wheaton; TL Gentles; LE Grigg; RN Justo; DJ Radford; C Attard; R G.Weintraub; A Bullock; GS Sholler; DS Celermajer; Y d'Udekem

Journal article

No difference between aspirin and warfarin after extracardiac Fontan in a propensity score analysis of 475 patients

AJ Iyengar, D S.Winlaw, JC Galati, GR Wheaton, TL Gentles, LE Grigg, RN Justo, DJ Radford, C Attard, R G.Weintraub, A Bullock, GS Sholler, DS Celermajer, Y d'Udekem

European Journal of Cardio Thoracic Surgery | OXFORD UNIV PRESS INC | Published : 2016

DOI: 10.1093/ejcts/ezw159

Abstract

OBJECTIVES: The most effective method of long-term thromboprophylaxis after the Fontan procedure is not clear. We compared the rates of thromboembolic events between patients receiving aspirin and warfarin after an extracardiac conduit Fontan procedure in a bi-national registry. METHODS: All patients who underwent an extracardiac conduit Fontan procedure from 1997 to 2010 in Australia and New Zealand were identified. Medication status and routine follow-up and echocardiographic data were obtained from all patients. Survival analysis with propensity score matching and adjustment was performed to determine the treatment effect of warfarin compared with that of aspirin beyond the first year of ..

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University of Melbourne Researchers

Robert Weintraub Author

Yves D'Udekem D'Acoz Author

Related Projects (1)

IMPROVING FUNCTIONAL OUTCOMES AFTER FONTAN SURGERY BY A CROSS-SECTIONAL STUDY OF THE OUTCOMES FOLLOWING VARIATION IN PRACTICE IN AUSTRALIA AND NEW ZEALAND: FOCUS ON ANTICOAGULATION AND CARDIAC SHUNTING BY THE FENESTRATION

The Fontan procedure is the last of a series of life-saving operations offered to children born with only one pumping chamber in their heart..

Grants

Awarded by Murdoch Children's Research Institute

Funding Acknowledgements

Ajay J. Iyengara has received postgraduate awards from the Royal Australasian College of Surgeons (Catherine Marie Enright Kelly and Eric Bishop Scholarships) and the National Health and Medical Research Council (NHMRC) and The National Heart Foundation of Australia (1038802). Yves d'Udekem is a Career Development Fellow of The National Heart Foundation of Australia (CR 10M 5339). This research project was supported by the Victorian Government's Operational Infrastructure Support Program. The Australia and New Zealand Fontan Registry is funded by grants from the NHMRC (project grants 1012241, 1047923 and 1065794) HeartKids and the ANZ Bank Trustees.