The Fontan epidemic: Population projections from the Australia and New Zealand Fontan Registry
Chris Schilling, Kim Dalziel, Russell Nunn, Karin Du Plessis, William Y Shi, David Celermajer, David Winlawf, Robert G Weintraub, Leanne E Grigg, Dorothy J Radford, Andrew Bullock, Thomas L Gentles, Gavin R Wheaton, Tim Hornung, Robert N Justo, Yves d'Udekem
INTERNATIONAL JOURNAL OF CARDIOLOGY | ELSEVIER IRELAND LTD | Published : 2016
BACKGROUND: The number and age demographic of the future Fontan population is unknown. METHODS: Population projections were calculated probabilistically using microsimulation. Mortality hazard rates for each Fontan recipient were calculated from survivorship of 1353 Fontan recipients in the Australia and New Zealand Fontan Registry, based on Fontan type, age at Fontan, gender and morphology. Projected rates of new Fontan procedures were generated from historical rates of Fontan procedures per population births. RESULTS: At the end of 2014, the living Fontan population of Australia and New Zealand was 1265 people from an Australian and New Zealand regional population of 28 million (4.5 per 10..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC)
Awarded by NHMRC
The Australia and New Zealand Fontan Registry is funded by grants from the National Health and Medical Research Council (NHMRC; Project Grants 1012241, 1047923, 1065794). The authors acknowledge support provided to the Murdoch Childrens Research Institute by the Victorian Government's Operational Infrastructure Support Program. Yves d'Udekem is a NHMRC Clinical Practitioner Fellow (1082186) as well as the Principal Investigator and recipient of the NHMRC Partnership Project (1076849). The Victorian Government's Operational Infrastructure Support Program supported this research project.