Clinical studies in dermatology require a post-treatment observation phase to define the impact of the intervention on the natural history of the complaint
Rodney Sinclair, Graham A Turner, D Andrew R Jones, Shengjun Luo
Archives of Dermatological Research | SPRINGER | Published : 2016
The use of a post-treatment period of observation or "regression phase" is common in pharmaceutical and cosmetic clinical dermatology studies. Regression phases can be incorporated into a variety of study designs, ranging from simple post-treatment observation for a defined period, as has been used for moisturizers, antidandruff formulations, and treatments for acne, to more complex randomized intermittent-treatment designs, as used in studies of psoriasis pharmacotherapies. Extensive information can be derived from a regression phase. Notably, it can provide useful data on the persistence of effect and time to relapse after treatment cessation, which are particularly relevant to skin condit..View full abstract
Funding for editorial assistance was provided by Unilever Research & Development, Port Sunlight, UK.