Journal article

Quantitative Fundus Autofluorescence in Early and Intermediate Age-Related Macular Degeneration

Martin Gliem, Philipp L Mueller, Robert P Finger, Myra B McGuinness, Frank G Holz, Peter Charbel Issa



IMPORTANCE: Increased lipofuscin accumulation is assumed to be an important factor in the pathogenesis of age-related macular degeneration (AMD), although direct evidence for this hypothesis is missing. OBJECTIVE: To quantitatively investigate lipofuscin-associated fundus autofluorescence (AF) in patients with early and intermediate AMD. DESIGN, SETTING, AND PARTICIPANTS: A prospective, single-center, case-control study was conducted from August 1, 2014, to October 31, 2015, at a university referral center. Participants included 40 patients aged 65 years or younger and 108 individuals without eye disease serving as controls. All participants underwent quantitative fundus AF (qAF) imaging wit..

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Awarded by National Health and Medical Research Council Centre for Clinical Research Excellence

Funding Acknowledgements

This work was supported by the ProRetina Deutschland, the BONFOR research program of the University of Bonn, and grant 529923 from the National Health and Medical Research Council Centre for Clinical Research Excellence. The Department of Ophthalmology, University of Bonn, receives imaging devices from Heidelberg Engineering; Centre for Eye Research Australia receives Operational Infrastructure Support from the Victorian government.