Journal article

Understanding the Pathogenicity of Noncoding Mismatch Repair Gene Promoter Variants in Lynch Syndrome

Qing Liu, Bryony A Thompson, Robyn L Ward, Luke B Hesson, Mathew A Sloane

Human Mutation | WILEY | Published : 2016

DOI: 10.1002/humu.22971

University of Melbourne Researchers

Related Projects (1)

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Identification Of Novel Colorectal Cancer Susceptibility Genes

Colon cancer is one of the most common cancers, with around 1 million cases diagnosed annually. These cancers can be caused by a combination..

Grants

Awarded by Cancer Institute NSW

Awarded by NHMRC Early-Career Fellowship

Funding Acknowledgements

Contract grant sponsors: Cancer Institute NSW (to R. L. D.); Cancer Council NSW (RG13-07 to R. L. D.); NHMRC Early-Career Fellowship (1091211 to B. A. T.).

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Keywords

Methylation
Dna Mismatch Repair
Gene Expression Regulation, Neoplastic
Dna-Binding Proteins
Humans
Sequence Variants
10-Mb Paracentric Inversion
Mutl Protein Homolog 1
Msh2 Genes
5 ' Utr
Cancer Susceptibility
X-Chromosome
Mismatch Repair Endonuclease Pms2
Promoter Regions, Genetic
Promoter
Genetic Variation
Colorectal Neoplasms, Hereditary Nonpolyposis
Mlh1 Epimutation
Noncoding Variant
Genetic Predisposition To Disease
Expression
Transcription Factor
Life Sciences & Biomedicine
Muts Homolog 2 Protein
Mutations
5′ Utr
Genetics & Heredity
Nonpolyposis Colorectal-Cancer
Science & Technology
Lynch Syndrome