Effects of pulsatile electrical stimulation of the round window on central hyperactivity after cochlear trauma in guinea pig
WHAM Mulders, TC Spencer, D Robertson
HEARING RESEARCH | ELSEVIER SCIENCE BV | Published : 2016
Partial hearing loss induced by acoustic trauma has been shown in animal models to result in an increased spontaneous firing rate in central auditory structures. This so-called hyperactivity has been suggested to be involved in the generation of tinnitus, a phantom auditory sensation. Although there is no universal cure for tinnitus, electrical stimulation of the cochlea, as achieved by a cochlear implant, can result in significant reduction of the tinnitus percept. However, the mechanism by which this tinnitus suppression occurs is as yet unknown and furthermore cochlear implantation may not be an optimal treatment option for tinnitus sufferers who are not profoundly deaf. A better understa..View full abstract
Awarded by National Health and Medical Research Council (NHMRC)
Awarded by Department of Health WA
This work was supported by grants from the National Health and Medical Research Council (NHMRC: APP1042623), the Medical Health and Research Infrastructure Fund (Australia), Department of Health WA (WADOH1060493) and The University of Western Australia.