Stage-specific analysis of plasma protein profiles in ovarian cancer: Difference in-gel electrophoresis analysis of pooled clinical samples.
Mark J Bailey, Kristy L Shield-Artin, Karen Oliva, Mustafa Ayhan, Simone Reisman, Gregory E Rice
Journal of Carcinogenesis | Published : 2013
INTRODUCTION: Ovarian cancer is the leading cause of death from gynecological cancer. Non-specific symptoms early in disease and the lack of specific biomarkers hinder early diagnosis. Multi-marker blood screening tests have shown promise for improving identification of early stage disease; however, available tests lack sensitivity, and specificity. MATERIALS AND METHODS: In this study, pooled deeply-depleted plasma from women with Stage 1, 2 or 3 ovarian cancer and healthy controls were used to compare the 2-dimensional gel electrophoresis (2-DE) protein profiles and identify potential novel markers of ovarian cancer progression. RESULTS/DISCUSSION: Stage-specific variation in biomarker exp..View full abstract