Journal article
Replication of an association of a promoter polymorphism of the dopamine transporter gene and Attention Deficit Hyperactivity Disorder
C Doyle, K Brookes, J Simpson, J Park, S Scott, DR Coghill, Z Hawi, A Kirley, M Gill, L Kent
Neuroscience Letters | ELSEVIER IRELAND LTD | Published : 2009
Abstract
Genetic associations for Attention Deficit Hyperactivity Disorder (ADHD), a common highly heritable childhood behavioural disorder, require replication in order to establish whether they are true positive findings. The current study aims to replicate recent association findings from the International Multi-centre ADHD Genetics (IMAGE) project in one of the most studied genes related to ADHD, the dopamine transporter (DAT1) gene. In a family-based sample of 450 ADHD probands, three Single Nucleotide Polymorphism (SNP) markers have been genotyped using TaqMan assays. Transmission Disequilibrium Test analysis demonstrates that one of three SNP markers (rs11564750) in the 5′ promoter region of t..
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Funding Acknowledgements
The sample collection for this project was partly funded by the Wellcome Trust (LK) and with generous support from the Health Research Board, Dublin (ZH, MB and EB). The authors declare that there are no competing interests. We would like to thank all the families involved in the study for their participation.