Effect of extended release stimulant-based medications on neuropsychological functioning among adolescents with Attention-Deficit/Hyperactivity Disorder

Abstract

Attention-Deficit/Hyperactivity Disorder (ADHD) is associated with diminished neuropsychological functioning. This randomized, double-blind, placebo controlled, study is the first comparison of two extended release stimulant-based medications (Adderall XR® and Concerta®) and placebo on ADHD neuropsychological functioning. Adolescents diagnosed with ADHD (n = 35, 19 males) completed three separate assessments (5, 8, 11 p.m.) on three different days and medications (Concerta,® Adderall XR® and Placebo). The assessments consisted of two different neuropsychological tests, the Delayed Matching-to-Sample and the Go/No-go (GNG), which measure visual memory, attention span, and response inhibition...