Journal article
The N -Methyl d -Aspartate Glutamate Receptor Antagonist Ketamine Disrupts the Functional State of the Corticothalamic Pathway
PM Anderson, NC Jones, TJ O'Brien, D Pinault
Cerebral Cortex | OXFORD UNIV PRESS INC | Published : 2017
Abstract
The non-competitive N-methyl d-aspartate glutamate receptor (NMDAR) antagonist ketamine elicits a brain state resembling high-risk states for developing psychosis and early stages of schizophrenia characterized by sensory and cognitive deficits and aberrant ongoing gamma (30-80 Hz) oscillations in cortical and subcortical structures, including the thalamus. The underlying mechanisms are unknown. The goal of the present study was to determine whether a ketamine-induced psychotic-relevant state disturbs the functional state of the corticothalamic (CT) pathway. Multisite field recordings were performed in the somatosensory CT system of the sedated rat. Baseline activity was challenged by activa..
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Funding Acknowledgements
The present work was supported by the French National Institute of Health and Medical Research (Institut National de la Sante et de la Recherche Medicale), l'Universite de Strasbourg, la Fondation pour la Recherche Medicale, and Neurex. P.M.A. received a 2012 Australian Endeavour Research Fellowship Award.