Journal article

Multiplex Assay for Simultaneous Detection of Mycoplasma genitalium and Macrolide Resistance Using PlexZyme and PlexPrime Technology

Sepehr N Tabrizi, Lit Y Tan, Samantha Walker, Jimmy Twin, Marin Poljak, Catriona S Bradshaw, Christopher K Fairley, Melanie Bissessor, Elisa Mokany, Alison V Todd, Suzanne M Garland

PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2016


Mycoplasma genitalium is a cause of non-gonoccocal urethritis (NGU) in men and cervicitis and pelvic inflammatory disease in women. Recent international data also indicated that the first line treatment, 1 gram stat azithromycin therapy, for M. genitalium is becoming less effective, with the corresponding emergence of macrolide resistant strains. Increasing failure rates of azithromycin for M. genitalium has significant implications for the presumptive treatment of NGU and international clinical treatment guidelines. Assays able to predict macrolide resistance along with detection of M. genitalium will be useful to enable appropriate selection of antimicrobials to which the organism is susce..

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Funding Acknowledgements

In regards to the funding statement the authors would like to confirm that the funder (SpeedX) provided support in the form of salaries for authors (LT, SW, EM, AT). The funder did not have any role in the clinical evaluation including data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulated in the 'author contributions' section.