Journal article

Proteinuria and lipoprotein lipase activity in Miniature Schnauzer dogs with and without hypertriglyceridemia

E Furrow, JQ Jaeger, VJ Parker, KW Hinchcliff, SE Johnson, SJ Murdoch, IH de Boer, RG Sherding, JD Brunzell

The Veterinary Journal | ELSEVIER SCI LTD | Published : 2016

Abstract

Spontaneous hyperlipidemia in rats causes glomerular disease. Idiopathic hypertriglyceridemia (HTG) is prevalent in Miniature Schnauzers, but its relationship with proteinuria is unknown. Decreased activity of major lipid metabolism enzymes, lipoprotein lipase (LPL) and hepatic lipase (HL), may play a role in the cyclic relationship between hyperlipidemia and proteinuria. These enzymes have also not been previously investigated in Miniature Schnauzers. The aims of this study were to determine the relationship between HTG and proteinuria in Miniature Schnauzers and to measure LPL and HL activities in a subset of dogs. Fifty-seven Miniature Schnauzers were recruited (34 with and 23 without HTG..

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Grants

Awarded by Ohio State University Canine Research Foundation


Awarded by Morris Animal Foundation


Awarded by NIH ORIP K01 Mentored Research Scientist Development Award


Awarded by OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH


Funding Acknowledgements

The research was funded by a donation from Mr and Mrs James and Virginia Squeo, the Ohio State University Canine Research Foundation Grant (2000-46) and a Morris Animal Foundation grant (D12CA-031). Partial funding for Dr Furrow is provided by an NIH ORIP K01 Mentored Research Scientist Development Award (K01OD019912). The authors thank Aaron Rendahl for statistical support, the Medical Records Department at The Ohio State University Veterinary Medical Center for maintaining and providing medical records, and the Center for Investigative Studies at the University of Minnesota Veterinary Medical Center for recruiting dogs and collecting samples for the study. Preliminary results of the study were presented as an abstract at the 2003 American College of Veterinary Internal Medicine (ACVIM) Forum in Charlotte, NC, USA, a scientific session at the 2013 ACVIM Forum in Seattle, WA, USA and a research report at the 2015 ACVIM Forum in Indianapolis, IN, USA. A subset of this work was a chapter in Dr Jaeger's thesis submitted to the Faculty of the Graduate School of the Ohio State University in partial fulfillment of the requirements for a Master of Science (MS) degree.