Gonadal dysgenesis: Associations between clinical features and sex of rearing

Abstract

The purpose of this study was to review the phenotypic and endocrine features of a series of patients with ambiguous genitalia or sex-reversal due to gonadal dysgenesis (GD) and to analyse the impact of these on the decision about sex of rearing. This study is a retrospective analysis of 22 patients with GD treated between 1964 and 1994. We assessed external genitalia, internal genital structures, gonadal morphology (n=22), basal and human CG (hCG) stimulated serum testosterone levels (n=11) and serum gonadotropin levels (n=13) in patients with GD. Basal and hCG stimulated testosterone levels were also measured for 43 control patients. There were no significant associations or correlations b..