Journal article
Perioperative risk factors for impaired neurodevelopment after cardiac surgery in early infancy
Julia K Gunn, John Beca, Rodney W Hunt, Michelle Goldsworthy, Christian P Brizard, Kirsten Finucane, Susan Donath, Lara S Shekerdemian
ARCHIVES OF DISEASE IN CHILDHOOD | BMJ PUBLISHING GROUP | Published : 2016
Abstract
OBJECTIVE: Historical cohort studies have reported adverse neurodevelopment following cardiac surgery during early infancy. Advances in surgical techniques and perioperative care have coincided with updating of neurodevelopmental assessment tools. We aimed to determine perioperative risk factors for impaired neurodevelopment at 2 years following surgery for congenital heart disease (CHD) in early infancy. DESIGN AND PATIENTS: We undertook a prospective longitudinal study of 153 full-term infants undergoing surgery for CHD before 2 months of age. Infants were excluded if they had a genetic syndrome associated with neurodevelopmental impairment. OUTCOME MEASURES: Predefined perioperative param..
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Funding Acknowledgements
The study was supported from the National Heart Foundation (Australia), Heart Foundation of New Zealand, Auckland Medical Research Fund, Green Lane Research and Education Fund, Australian and New Zealand Intensive Care Foundation, MCRI and the Victorian Government's Operational Infrastructure Support Program. Dr Gunn received a Career Development Award from MCRI. The study sponsors played no role in the research nor production of this manuscript.