Engineered Metal-Phenolic Capsules Show Tunable Targeted Delivery to Cancer Cells

Yi Ju; Jiwei Cui; Huanli Sun; Markus Mullner; Yunlu Dai; Junling Guo; Nadja Bertleff-Zieschang; Tomoya Suma; Joseph J Richardson; Frank Caruso

Journal article

Engineered Metal-Phenolic Capsules Show Tunable Targeted Delivery to Cancer Cells

Yi Ju, Jiwei Cui, Huanli Sun, Markus Mullner, Yunlu Dai, Junling Guo, Nadja Bertleff-Zieschang, Tomoya Suma, Joseph J Richardson, Frank Caruso

BIOMACROMOLECULES | AMER CHEMICAL SOC | Published : 2016

DOI: 10.1021/acs.biomac.6b00537

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Abstract

We engineered metal-phenolic capsules with both high targeting and low nonspecific cell binding properties. The capsules were prepared by coating phenolic-functionalized hyaluronic acid (HA) and poly(ethylene glycol) (PEG) on calcium carbonate templates, followed by cross-linking the phenolic groups with metal ions and removing the templates. The incorporation of HA significantly enhanced binding and association with a CD44 overexpressing (CD44+) cancer cell line, while the incorporation of PEG reduced nonspecific interactions with a CD44 minimal-expressing (CD44-) cell line. Moreover, high specific targeting to CD44+ cells can be balanced with low nonspecific binding to CD44- cells simply b..

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University of Melbourne Researchers

Frank Caruso Author Chemical Engineering

Jiwei Cui Author Chemical Engineering

Yi Ju Author Microbiology and Immunology

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Grants

Awarded by Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology

Awarded by ARC

Funding Acknowledgements

This work was conducted and funded by the Australian Research Council (ARC) Centre of Excellence in Convergent Bio-Nano Science and Technology (project number CE140100036). This work was also supported by the ARC under the Australian Laureate Fellowship (F.C., FL120100030) and Super Science Fellowship (F.C., FS110200025) schemes. This work was performed in part at the Materials Characterisation and Fabrication Platform (MCFP) at the University of Melbourne and the Victorian Node of the Australian National Fabrication Facility (ANFF).