Journal article
Cortical morphometry in attention deficit/hyperactivity disorder: Contribution of thickness and surface area to volume
TJ Silk, R Beare, C Malpas, C Adamson, V Vilgis, A Vance, MA Bellgrove
Cortex | ELSEVIER MASSON | Published : 2016
Abstract
Although lower brain volume is a consistent neuroimaging finding in attention deficit hyperactivity disorder (ADHD), we lack an understanding of whether this effect is driven by changes in cortical thickness or surface area, which are governed by distinct neurodevelopmental processes. This study examined ADHD-control differences in cortical thickness, surface area and volume, and tests whether thickness and surface area mediates any observed volume differences. Magnetic resonance imaging (MRI) data was collected from 35 males with ADHD-combined type and 35 typically developing control participants aged 9-17 years. Morphometric measures were examined for between group differences and the spec..
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Awarded by Royal Children's Hospital Foundation
Funding Acknowledgements
This work was supported by a Project Grant to MAB and AV (No. 569533) and AV (No. 384419) from the National Health and Medical Research Council of Australia. The research was conducted within the Academic Child Psychiatry Unit, University of Melbourne, Royal Children's Hospital and the Developmental Imaging research group, Murdoch Childrens Research Institute (MCRI) and the Children's MRI Centre, Royal Children's Hospital, Melbourne, Victoria. It was also supported by The Royal Children's Hospital Foundation and the Victorian Government's Operational Infrastructure Support Program. TS was supported by a NHMRC Career Development Award (1004637).