Journal article

Polymorphisms in the CD14 and TLR4 genes independently predict CD4( ) T-cell recovery in HIV-infected individuals on antiretroviral therapy

Yean K Yong, Esaki M Shankar, Ajantha Solomon, Tim Spelman, Christopher K Fairley, Julian H Elliott, Jennifer Hoy, Paul U Cameron, Adeeba Kamarulzaman, Sharon R Lewin

AIDS | LIPPINCOTT WILLIAMS & WILKINS | Published : 2016

Abstract

BACKGROUND: Chronic HIV infection leads to marked depletion of CD4 T cells in the gastrointestinal tract and increased microbial translocation measured by an increase in circulating lipopolysaccharide (LPS) levels. Here, we hypothesized that single-nucleotide polymorphisms (SNPs) in genes encoding the Toll-like receptor 4 (TLR4) and CD14, the principal receptors for LPS, were associated with CD4 T-cell recovery postantiretroviral therapy (ART). METHODS: Prospective study of predominantly white HIV-infected participants receiving suppressive ART for at least 12 months. We analysed the CD14 SNPs C-260T and the TLR4 SNPs A+896G, C+1196T. We also determined the levels of LPS and soluble CD14 in ..

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Grants

Awarded by High Impact Research-Ministry of Higher Education, Malaysia


Awarded by University of Malaya Research Grant (UMRG) by Health and Translational Medicine Research Cluster


Awarded by Delaney AIDS Research Enterprise (DARE), National Institutes of Health


Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES


Funding Acknowledgements

The work was supported by a grant from the High Impact Research-Ministry of Higher Education, Malaysia (UM.C/625/1/HIR/MOHE/MED/ 01), University of Malaya Research Grant (UMRG) (RG448-12HTM) by the Health and Translational Medicine Research Cluster to E.M.S. S.R.L. is supported by the National Health and Medical Research Council of Australia and the Delaney AIDS Research Enterprise (DARE), National Institutes of Health (U19 AI096109).