Effects Of treadmill training on hindlimb muscles of spinal cord-injured mice
Camila R Battistuzzo, Michelle M Rank, Jamie R Flynn, David L Morgan, Robin Callister, Robert J Callister, Mary P Galea
MUSCLE & NERVE | WILEY | Published : 2017
INTRODUCTION: Treadmill training is known to prevent muscle atrophy after spinal cord injury (SCI), but the training duration required to optimize recovery has not been investigated. METHODS: Hemisected mice were randomized to 3, 6, or 9 weeks of training or no training. Muscle fiber type composition and fiber cross-sectional area (CSA) of medial gastrocnemius (MG), soleus (SOL), and tibialis anterior (TA) were assessed using ATPase histochemistry. RESULTS: Muscle fiber type composition of SCI animals did not change with training. However, 9 weeks of training increased the CSA of type IIB and IIX fibers in TA and MG muscles. CONCLUSIONS: Nine weeks of training after incomplete SCI was effect..View full abstract
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Awarded by National Health and Medical Research Council
This study was supported by a grant from the National Health and Medical Research Council Project (Project No. 628765). C.R.B. was supported by a Melbourne International Research Scholarship from the University of Melbourne.